Anti-c-Myc antibody produced in rabbit, approx. 0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Code: C3956-.2MG D2-231

Application

Antibody is recommended for use in immunoblotting, immunoprecipitation and immunofluorescence..

Anti-c-Myc antibody has been used in western blotting and im...


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€730.90 EACH
€899.01 inc. VAT

Application

Antibody is recommended for use in immunoblotting, immunoprecipitation and immunofluorescence..

Anti-c-Myc antibody has been used in western blotting and immunofluorescence.

Biochem/physiol Actions

MYC (MYC proto-oncogene) may be essential for cancer initiation, promotion and therapy resistance. Overexpression of MYC in DLBCL (diffuse large B-cell lymphoma) results in poor outcome and invasive treatment when medicated with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). The cellular myelocytomatosis (c-myc) oncogene plays a major role in cellular proliferation, differentiation and apoptosis. It acts as transcriptional regulator of gene expression.

General description

MYC (MYC proto-oncogene) is a transcriptional factor and oncoprotein. It is located on chromosome 8q24. c-Myc gene codes for basic helix-loop-helix/leucine zipper (bHLH/LZ) transcription factor.

Anti-c-Myc antibody is used for the detection of the c-Myc tag sequence on c-Myc tagged fusion proteins.This polyclonal antibody is produced in rabbit and recognizes the c-Myc sequence at the N-terminus and C-terminus. C3956 is an Affinity purified antibody, increasing sensitivity in most applications.

Immunogen

peptide corresponding amino acids 408-425 of the human c-myc proto-oncogene, conjugated to maleimide-activated KLH through a C-terminal added cysteine residue.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Specificity

N-terminal or C-terminal c-Myc (Glu-Gln-Lys-Leu-Ile-Ser-Glu-Glu-Asp-Leu) tagged fusion proteins.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration~0.5 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... MYC(4609)
Quality Level200
species reactivityhuman
storage temp.−20°C
technique(s)immunoprecipitation (IP): 1-2 µg using immunoprecipitates a c-Myc fusion protein from transfected mammalian cell lysates or bacterial extracts, microarray: suitable, immunocytochemistry: 5-10 µg/mL, indirect immunofluorescence: 5-10 µg/mL using detects c-Myc fusion proteins in methanol-acetone fixed transiently transfected cells, western blot: 0.5-1 µg/mL using detects c-Myc fusion proteins in cell extracts from transfected cultures as well as bacterial lysates.
UniProt accession no.P01106
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